Metabolism of 2,3,7,8-tetrachlorodibenzofuran in the rat

Journal Article · Sun Jan 01 04:00:00 EST 1984 · Chemosphere; (United States)

DOI:https://doi.org/10.1016/0045-6535(84)90142-5· OSTI ID:5928805

Poiger, H; Buser, H R; Schlatter, C

Single doses of 2,3,7,8-tetrachlorodibenzofuran (2378-TCDF) were administered orally to bile duct cannulated rats and bile collected for up to 48 hours. The bile was analyzed for the parent compound and metabolites. In organic extracts, which had been methylated and purified by TLC, 13 chlorinated metabolites were detected that were not present in the bile of untreated animals. Four of these, tetrachloromethoxy-, trichloromethoxy- and two trichlorodimethoxy-dibenzofuran isomers were present in major amounts. The remaining compounds, found only in minor or trace amounts very likely originate from other chlorinated dibenzofurans present as impurities in 2378-TCDF. No parent compound was detected in these samples.

• Research Organization: Univ. of Zurich, Switzerland
• OSTI ID: 5928805
• Journal Information: Chemosphere; (United States), Journal Name: Chemosphere; (United States) Vol. 13:2; ISSN CHESB
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZOFURANS
BILE
BILIARY TRACT
BIOLOGICAL MATERIALS
BODY FLUIDS
CHLORINATED AROMATIC HYDROCARBONS
CHROMATOGRAPHY
DIGESTIVE SYSTEM
FURANS
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
MAMMALS
MATERIALS
METABOLISM
METABOLITES
ORAL ADMINISTRATION
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
RATS
RODENTS
SEPARATION PROCESSES
THIN-LAYER CHROMATOGRAPHY
VERTEBRATES