C15-C18 isomers synthesized from ( TC)-2,3,7,8-tetrachlorodibenzofuran via surface chlorination
At present, the identification and quantitation of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) is performed with GC/MS/DS systems and is facilitated by using relative retention times and relative response factors based on ( TC)-isotopically labelled 2,3,7,8-TCDD, 2,3,7,8- TCDF, and OCDD. These compounds are used as internal standards for the analysis for TCDD, TCDF, and OCDD respectively and as surrogates for the analysis for penta, hexa, hepta chlorinated dibenzo-p-dioxin and dibenzofuran isomers and octachlorodibenzofuran. The use of isotopically labelled internal standards for all chlorination levels of dibenzo-p-dioxin and dibenzofuran would greatly improve the quality of currently generated analytical data from the analysis of various matrices for tetrachloro-through octachlorodibenzo-p-dioxins and dibenzofurans. However, these compounds are difficult to obtain commercially and are quite expensive to be adding to every sample prior to extraction. To circumvent these drawbacks in the scheme of analysis for PCDFs, the polychlorination of ( TC)-2,3,7,8-TCDF was attempted and accomplished using a method based on previously published work that started with ( TC)-2,3,7,8-TCDD. After synthesis and quantitation of the labelled products, they can be added to a matrix before extraction and work up and used as true internal standards as opposed to surrogates.
- Research Organization:
- California Analytical Labs., Inc., Sacramento
- OSTI ID:
- 6163425
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 38:3; ISSN BECTA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
BENZOFURANS
CALIBRATION STANDARDS
CARBON 13
CARBON ISOTOPES
CHEMICAL PREPARATION
CHEMICAL REACTIONS
CHLORINATION
CHROMATOGRAPHY
EVEN-ODD NUCLEI
FURANS
GAS CHROMATOGRAPHY
HALOGENATION
HETEROCYCLIC COMPOUNDS
ISOMERS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
NUCLEI
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
SEPARATION PROCESSES
STABLE ISOTOPES
STANDARDS
SYNTHESIS