Uses of available record systems in epidemiologic studies of reproductive toxicology

Journal Article · Fri Dec 31 23:00:00 EST 1982 · Am. J. Ind. Med.; (United States)

DOI:https://doi.org/10.1002/ajim.4700040124· OSTI ID:5927352

Polednak, A P; Janerich, D T

The uses of available record systems in epidemiologic studies of reproductive toxicology are described with reference to New York State. The available record systems (and relevant reproductive end points) described include: a newborn screening program for metabolic diseases and hemoglobinopathies (relevant to point mutations); chromosome registries and prenatal cytogenetics (for chromosome anomalies); live birth certificates (for birth defects, birthweight, sex ratio, etc); fetal death certificates (for spontaneous fetal deaths); and a statewide cancer registry (for childhood cancers and transplacental carcinogenesis). The uses and limitations of these record systems are discussed, along with examples of their use in descriptive and analytic epidemiologic studies. Descriptive studies outlined include investigations of temporal and geographic trends in birth defects, birth weight, and fetal deaths, with reference to environmental questions (eg, Love Canal, nuclear power plants). Analytic studies described concern parental occupation in relation to specific birth defects (neural tube defects and Down syndrome) and maternal use of contraceptive drugs.

• Research Organization: Division of Community Health and Epidemiology, New York State Department of Health, Albany
• OSTI ID: 5927352
• Journal Information: Am. J. Ind. Med.; (United States), Journal Name: Am. J. Ind. Med.; (United States) Vol. 4:1-2; ISSN AJIMD
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARCINOMAS
CHROMOSOMAL ABERRATIONS
CONGENITAL MALFORMATIONS
DATA PROCESSING
DEATH
DISEASES
ENVIRONMENT
EPIDEMIOLOGY
FEDERAL REGION II
HEREDITARY DISEASES
HUMAN POPULATIONS
MALFORMATIONS
METABOLIC DISEASES
MUTATIONS
NEOPLASMS
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NORTH AMERICA
OCCUPATIONAL DISEASES
PATHOLOGICAL CHANGES
POLLUTION
POPULATIONS
PROCESSING
USA
WATER POLLUTION