Time course of exercise-induced bronchoconstriction in asthmatics exposed to sulfur dioxide

Journal Article · Wed Aug 01 04:00:00 EDT 1984 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(84)90100-2· OSTI ID:5926242

Hackney, J D; Linn, W S; Bailey, R M; Spier, C E; Valencia, L M

Young adult asthmatic volunteers (N = 17) were exposed to 0.75 ppM sulfur dioxide (SO/sub 2/) for 3-hr periods, exercising vigorously for the first 10 min and resting thereafter. Specific airway resistance (SR/sub aw/) and symptoms were recorded preexposure, immediately postexercise, and after 1, 2, and 3 hr of exposure. Symptoms and SR/sub aw/ were significantly increased after exercise, relative to preexposure measurements. Group mean SR/sub aw/ and symptom increases were no longer significant at 1 hr. In a few individuals, effects may have persisted for 2 hr or more. On separate occasions, comparable exposures were conducted, and forced expiratory spirometry was performed preexposure and postexercise, in addition to the other tests. Inclusion of spirometry did no significantly affect the other results. Spirometry and SR/sub aw/ showed nearly equal significance in changes postexercise. Thus, in general, asthmatics bronchoconstriction induced by exercise in SO/sub 2/ seems to reverse quickly with rest, even if SO/sub 2/ exposure continues. Spirometry may be useful for studying pollution-induced bronchoconstriction when SR/sub aw/ measurements are impractical.

• Research Organization: Univ. of Southern California, Downey
• OSTI ID: 5926242
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 34:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ASTHMA
BIOLOGICAL EFFECTS
BODY
BRONCHI
CHALCOGENIDES
DATA
DISEASES
DYNAMIC FUNCTION STUDIES
EXERCISE
EXPERIMENTAL DATA
INFORMATION
INHALATION
INTAKE
LUNGS
MEASURING METHODS
NUMERICAL DATA
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATIENTS
POLLUTION
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SIMULATION
SULFUR COMPOUNDS
SULFUR DIOXIDE
SULFUR OXIDES