Respiratory responses of young adult asthmatics to sulfur dioxide exposure under simulated ambient conditions

Journal Article · Fri Oct 01 04:00:00 EDT 1982 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(82)90022-6· OSTI ID:5814699

Linn, W S; Bailey, R M; Shamoo, D A; Venet, T G; Wightman, L H; Hackney, J D

Twenty-four young adult asthmatic volunteers were exposed to 0, 0.25, and 0.50 ppm SO/sub 2/ in random order at 1-week intervals. Exposures, conducted in a controlled-environment chamber at 23/sup 0/C and 90+% relative humidity, lasted 1 hr and incorporated alternating 10-min periods of moderate exercise (mean exercise ventilation about 27 liters/min) and rest. Airway resistance was measured before exposure, after the first exercise period, and near the end of exposure. Forced expiratory performance was measured after the final airway resistance measurement. Exposure-relatable symptoms were recorded before, during, and after exposure periods. None of these measures of response showed statistically significant variation attributable to SO/sub 2/, although small significant increases in resistance attributable to exercise were found. These negative results contrast with previous positive findings in asthmatics exposed to SO/sub 2/ via mouthpiece. The differences may relate to effects of mouthpiece breathing on respiratory defenses, or to interindividual variations in bronchial reactivity to SO/sub 2/.

• Research Organization: Univ. of Southern California, Downey
• OSTI ID: 5814699
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 29:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADULTS
AGE GROUPS
ANIMALS
ASTHMA
BIOLOGICAL EFFECTS
BODY
CHALCOGENIDES
DISEASES
DYNAMIC FUNCTION STUDIES
EXERCISE
LUNGS
MAMMALS
MAN
ORGANS
OXIDES
OXYGEN COMPOUNDS
PRIMATES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SULFUR COMPOUNDS
SULFUR DIOXIDE
SULFUR OXIDES
VERTEBRATES