Combined effect of sulfur dioxide and cold in exercising asthmatics
Journal Article
·
· Arch. Environ. Health; (United States)
Twenty-four asthmatic volunteers were exposed to 0, 0.3, and 0.6 ppm sulfur dioxide (SO/sub 2/) in purified background air at each of three temperatures - 21/sup 0/, 7/sup 0/, and -6/sup 0/C - in a controlled-environment chamber. Relative humidity was approximately 80%. Exposures consisted of 5 min heavy exercise periods plus brief warmup and cooldown periods. Airway resistance, thoracic gas volume, and symptoms were measured immediately before and after exposure. For the group, increasing SO/sub 2/ concentration and decreasing temperature were associated with statistically significant unfavorable effects on airway resistance and respiratory symptoms, as expected from previous findings. Effects of SO/sub 2/ and cold usually appeared to combine in an additive or less-than-additive fashion; there was little evidence of synergism. Individuals' response patterns were variable: a few suggested synergism, but others suggested a mitigating effect of cold on the bronchoconstrictive response to SO/sub 2/.
- Research Organization:
- Univ. of Southern California, Downey
- OSTI ID:
- 5606398
- Journal Information:
- Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 39:5; ISSN AEHLA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ASTHMA
ATMOSPHERES
BIOLOGICAL STRESS
BODY
BODY TEMPERATURE
CHALCOGENIDES
CONTROLLED ATMOSPHERES
DATA
DISEASES
DYNAMIC FUNCTION STUDIES
EXERCISE
HYPOTHERMIA
INFORMATION
LUNGS
NUMERICAL DATA
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATIENTS
POLLUTION
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RESPONSE MODIFYING FACTORS
STATISTICAL DATA
SULFUR COMPOUNDS
SULFUR DIOXIDE
SULFUR OXIDES
SYMPTOMS
SYNERGISM
TOXICITY
VARIATIONS
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ASTHMA
ATMOSPHERES
BIOLOGICAL STRESS
BODY
BODY TEMPERATURE
CHALCOGENIDES
CONTROLLED ATMOSPHERES
DATA
DISEASES
DYNAMIC FUNCTION STUDIES
EXERCISE
HYPOTHERMIA
INFORMATION
LUNGS
NUMERICAL DATA
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATIENTS
POLLUTION
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RESPONSE MODIFYING FACTORS
STATISTICAL DATA
SULFUR COMPOUNDS
SULFUR DIOXIDE
SULFUR OXIDES
SYMPTOMS
SYNERGISM
TOXICITY
VARIATIONS