Ethane 1-hydroxy-1, 1-diphosphonate (EHDP) counteracts the inhibitory effect of uranyl nitrate on bone formation

Journal Article · · Archives of Environmental Health; (USA)

DOI:https://doi.org/10.1080/00039896.1990.10118758· OSTI ID:5922110

Ubios, A M; Guglielmotti, M B ^[1]; Cabrini, R L ^[2]

---

1. Univ. of Buenos Aires (Argentina)
2. Univ. of Buenos Aires (Argentina) National Atomic Energy Commission, Buenos Aires (Argentina)

The beneficial effect of ethane 1-hydroxy-1, 1-diphosphonate (EHDP) in restoring the inhibition of bone formation in cases of acute uranium intoxication is presented. Bone formation was studied histomorphometrically in a model of alveolar bone healing. After tooth extraction, 40 rats were divided into 4 groups that received (1) no further treatment, (2) 10 daily intraperitoneal injections of 7.5 mg/kg of body weight of EHDP, (3) an intraperitoneal injection of 2.0 mg/kg of body weight of uranyl nitrate, and (4) the same treatment as was provided rats in groups 2 and 3. The results showed that the healing of bone did not occur in exposed animals, whereas healing in EHDP-treated exposed animals did not differ from that of nonexposed controls. This effect might result from a blocking and/or competitive action of EHDP and/or the stimulation that EHDP elicits at the doses and in the administration period studied.

• OSTI ID: 5922110
• Journal Information: Archives of Environmental Health; (USA), Journal Name: Archives of Environmental Health; (USA) Vol. 45:6; ISSN AEHLA; ISSN 0003-9896
• Country of Publication: United States
• Language: English

Related Subjects

550600* -- Medicine
550900 -- Pathology
560300 -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDES
ANIMAL TISSUES
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL RECOVERY
BODY
BONE MARROW
ELEMENTS
HAZARDS
HEALING
HEALTH HAZARDS
HEMATOPOIETIC SYSTEM
KINETICS
MAMMALS
METALS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHONATES
RATS
REACTION KINETICS
RECOVERY
RODENTS
TISSUES
URANIUM
VERTEBRATES