Synergism between two helper cell subpopulations characterized by different radiosensitivity and nylon adherence

Journal Article · Sun Mar 01 04:00:00 EST 1981 · J. Immunol.; (United States)

OSTI ID:5921975

Agarossi, G; Mancini, C; Doria, G

The present work extends our previous results on the radiosensitivity of the helper cell function. Two helper cell subpopulations, 1 radiosensitive and the other radioresistant, have been demonstrated in the spleen of mice at different times after priming with HRBC. The radiosensitive subpopulation increases with the increasing time interval between carrier-priming and irradiation. The 2 cell subpopulations have been further characterized by different nylon adherence properties: radioresistant helper cells adhere to nylon wool, whereas radiosensitive cells pass through. The 2 cell subpopulations were separated by x-irradiation and nylon wool filtration, and their helper activity was assessed separately or after recombination. The results favor the notion that 2 functionally independent helper T cells, as characterized by different radiosensitivity and nylon adherence, participate synergistically in the helper activity of primed spleen cells.

• OSTI ID: 5921975
• Journal Information: J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 126:3; ISSN JOIMA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
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CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
IMMUNITY
IMMUNOLOGY
IONIZING RADIATIONS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MOSAICISM
NYLON
ORGANIC COMPOUNDS
ORGANIC POLYMERS
ORGANS
PETROCHEMICALS
PETROLEUM PRODUCTS
PLASTICS
POLYAMIDES
POLYMERS
PROTEINS
RADIATION CHIMERAS
RADIATION EFFECTS
RADIATIONS
RADIOIMMUNOLOGY
RADIOSENSITIVITY
RODENTS
SOMATIC CELLS
SPLEEN
SPLEEN CELLS
SPLEEN COLONY FORMATION
SYNERGISM
SYNTHETIC MATERIALS
TIME DEPENDENCE
VERTEBRATES
X RADIATION