Synergism between two helper cell subpopulations characterized by different radiosensitivity and nylon adherence

Journal Article · Sun Mar 01 04:00:00 EST 1981 · J. Immunol.; (United States)

OSTI ID:5677559

Agarossi, G; Mancini, C; Doria, G

The present work extends our previous results on the radiosensitivity of the helper cell function. Two helper cell subpopulations, 1 radiosensitive and the other radioresistant, have been demonstrated in the spleen of mice at different times after priming with HRBC. The radiosensitive subpopulation increases with the increasing time interval between carrier-priming and irradiation. The 2 cell subpopulations have been further characterized by different nylon adherence properties: radioresistant helper cells adhere to nylon wool, whereas radiosensitive cells pass through. The 2 cell subpopulations were separated by x-irradiation and nylon wool filtration, and their helper activity was assessed separately or after recombination. The results favor the notion that 2 functionally independent helper T cells, as characterized by different radiosensitivity and nylon adherence, participate synergistically in the helper activity of primed spleen cells.

• Research Organization: CNEN-Euratom Immunogenetics Group, Rome, Italy
• OSTI ID: 5677559
• Journal Information: J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 126:3; ISSN JOIMA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIBODY FORMATION
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
DATA
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
INFORMATION
IONIZING RADIATIONS
MAMMALS
MATERIALS
MICE
NUMERICAL DATA
NYLON
ORGANIC COMPOUNDS
ORGANIC POLYMERS
PETROCHEMICALS
PETROLEUM PRODUCTS
PLASTICS
POLYAMIDES
POLYMERS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RODENTS
SOMATIC CELLS
SPLEEN CELLS
SYNERGISM
SYNTHETIC MATERIALS
VERTEBRATES
X RADIATION