Does local X-irradiation of a tumor increase the incidence of metastases

Journal Article · Tue Dec 01 04:00:00 EST 1981 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19811201)48:11<2394::AID-CNCR2820481110>3.0.CO;2-5· OSTI ID:5920725

Baker, D; Elkon, D; Lim, M L; Constable, W; Wanebo, H

KHT sarcomas were implanted into the right rear legs of C3H mice. Animals receiving no treatment died at 32 days with a 67% incidence of metastatic tumors. A dose of 6000 rads in ten fractions over 12 days, starting ten days after implant, delivered to the primary tumor (with the remainder of the body shielded) produced 55% local tumor control. However, 83% of the mice with local tumor control, subsequently developed metastatic lesions. Amputation of the tumor-bearing leg either prior to the start of radiation treatment, at the end of treatment or at intervals during treatment or sham treatment, indicated that 1) metastases occurred predominantly during the initial three radiation fractions and 2) the increased incidence of metastases following irradiation was a result of the manipulations associated with the irradiation and not the irradiation per se. Irradiation did not change the distribution of organ sites involved with metastic tumors compared to untreated or sham-treated tumors.

• Research Organization: Univ. of Virginia Medical Center, Charlottesville
• OSTI ID: 5920725
• Journal Information: Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 48:11; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
CARCINOGENESIS
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MAMMALS
METASTASES
MICE
NEOPLASMS
PATHOGENESIS
RADIATION DOSES
RADIATIONS
RADIOINDUCTION
RODENTS
SARCOMAS
VERTEBRATES
X RADIATION