The influence of ICRF-159 and levamisole on the incidence of metastases following local irradiation of a solid tumor

Journal Article · Sun Nov 15 04:00:00 EST 1981 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19811115)48:10<2179::AID-CNCR2820481011>3.0.CO;2-U· OSTI ID:5511386

Baker, D; Constable, W; Elkon, D; Rinehart, L

Courses of irradiation consisting of 6000 rad in ten equal fractions over 12 days delivered to KHT sarcomas in mice controlled 55% of the local tumors but 83% of the mice died from metastases. Three strategies to reduce the risk of metastatic spread were tested. The fractionation scheme was changed to deliver the same total dose using a large initial fraction followed by seven equal portions with the same overall time. ICRF-159 was used with the intention of partially synchronizing the tumor growth fraction in a radiosensitive state of the growth cycle and of promoting normalization of the tumor vasculature. Levamisole was used to stimulate the immune system. The combination of ICRF-159 with the eight-fraction radiation course proved to be effective for both increasing local control and decreasing the incidence of metastases. The addition of levamisole did not improve the results obtained with a combination of ICRF-159 and irradiation.

• Research Organization: University of Virginia Hospital, Charlottesville
• OSTI ID: 5511386
• Journal Information: Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 48:10; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOSES
FRACTIONATED IRRADIATION
IRRADIATION
MAMMALS
METASTASES
MICE
NEOPLASMS
RADIATION DOSES
RADIATION EFFECTS
RODENTS
SARCOMAS
VERTEBRATES