Influence of ICRF-159 and levamisole on the incidence of metastases following local irradiation of a solid tumor

Journal Article · Sun Nov 15 04:00:00 EST 1981 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19811115)48:10<2179::AID-CNCR2820481011>3.0.CO;2-U· OSTI ID:5762321

Baker, D; Constable, W; Elkon, D; Rinehart, L

Courses of irradiation consisting of 6000 rad in ten equal fractions over 12 days delivered to KHT sarcomas in mice controlled 55% of the local tumors but 83% of the mice died from metastases. Three strategies to reduce the risk of metastatic spread were tested. The fractionation scheme was changed to deliver the same total dose using a large initial fraction followed by seven equal portions with the same overall time. ICRF-159 was used with the intention of partially synchronizing the tumor growth fraction in a radiosensitive state of the growth cycle and of promoting normalization of the tumor vasculature. Levamisole was used to stimulate the immune system. The combination of ICRF-159 with the eight-fraction radiation course proved to be effective for both increasing local control and decreasing the incidence of metastases. The addition of levamisole did not improve the results obtained with a combination of ICRF-159 and irradiation.

• Research Organization: Univ. of Virginia Hospital, Charlottesville
• OSTI ID: 5762321
• Journal Information: Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 48:10; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL PROLIFERATION
CHEMOTHERAPY
DATA
DISEASES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
FRACTIONATED IRRADIATION
IMMUNOTHERAPY
INFORMATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MEDICINE
METASTASES
MICE
NEOPLASMS
NUCLEAR MEDICINE
NUMERICAL DATA
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
RODENTS
SARCOMAS
SURVIVAL TIME
THERAPY
VERTEBRATES
X RADIATION