Distribution and dosimetry of In-111 labeled leukocytes and platelets in humans

Conference · Mon Jun 01 00:00:00 EDT 1981 · HHS Publ. (FDA) (U.S.); (United States)

OSTI ID:5919838

Goodwin, D A ^[1]; Finston, R A; Smith, S I

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1. Veterans Administration Medical Center, Palo Alto, CA

The distribution of In-111 labeled leukocytes and platelets was studied by whole body gamma camera imaging in patients. Images were made approximately one hour and 24 hours after IV injection, and stored in digital form in computer memory. Estimates of the quantitative organ distribution were made from the geometric mean of the anterior and posterior region of interest counts after suitable background subtraction. Nearly quantitative retention of cell activity was observed with little or no excretion seen in either gut or kidneys. Mixed leukocytes distributed in spleen, liver and bone marrow in decreasing order of concentration, similar at both times, with a transient lung uptake noted at the one hour time only. The dose from 0.5 mCi In-111-WBC's was: liver, 1.4 rad; spleen, 8.5 rad; marrow, 2.3 rad. Lymphocytes had similar distribution with the addition of inguinal and cervical lymph nodes. The dose from 0.5 mCi In-111-lymphocytes was: liver, 0.8 rad; spleen, 6.7 rad; marrow and lymphatic tissue, 1.4 rad. Platelets distributed primarily in the blood pool with most of the remainder concentrating in the spleen, with a small amount in the penis. The dose from 0.5 mCi of In-111-platelets was: liver, 3.2 rad; spleen, 8.6 rad; and whole body, 0.3 rad.

• OSTI ID: 5919838
• Report Number(s): CONF-801082-; TRN: 82-003958
• Journal Information: HHS Publ. (FDA) (U.S.); (United States), Vol. 81-8166; Conference: ORAU radiopharmaceutical dosimetry symposium, Oak Ridge, TN, USA, 6 Oct 1980
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
INDIUM 111
DOSIMETRY
TISSUE DISTRIBUTION
ACCURACY
BIOLOGICAL LOCALIZATION
BLOOD PLATELETS
DIAGNOSTIC USES
GAMMA CAMERAS
IMAGES
LEUKOCYTES
PATIENTS
RADIATION DOSE DISTRIBUTIONS
RADIATION DOSES
RADIONUCLIDE KINETICS
TRACER TECHNIQUES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CAMERAS
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DOSES
ELECTRON CAPTURE RADIOISOTOPES
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPES
USES
560171* - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)
550601 - Medicine- Unsealed Radionuclides in Diagnostics