Platelet peripheral benzodiazepine receptors are decreased in Parkinson's disease

Journal Article · Tue Jan 01 04:00:00 EST 1991 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(91)90457-M· OSTI ID:5915649

Bonuccelli, U; Nuti, A; Del Dotto, P; Piccini, P; Martini, C; Giannacccini, G; Lucacchini, A; Muratorio, A ^[1]

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1. Univ. of Pisa (Italy)

Peripheral benzodiazepine (BDZ) receptors are located in a variety of tissues, including platelets, in the nuclear and/or mitochondrial membranes. The authors studied the density of peripheral BDZ receptors in platelets of 10 de novo Parkinson's disease (PD) patients, 18 PD patients treated with a levodopa/carbidopa combination, and in 15 healthy subjects matched for sex and age. The binding assay was conducted using ({sup 3}H)PK 11195, a specific ligand for peripheral BDZ receptors. A significant decrease in the density of ({sup 3}H)PK 11195 binding sites has been observed in PD patients with respect to controls but not between de novo and treated PD patients. No correlation has been found between the decrease in density of ({sup 3}H)PK 11195 binding sites in platelets and either the duration or severity of PD. Peripheral BDZ receptors are implicated in the regulation of mitochondrial respiratory function. Thus, their decrease in PD might parallel the abnormalities in mitochondrial function recently found in this neurologic disease.

• OSTI ID: 5915649
• Journal Information: Life Sciences; (USA), Journal Name: Life Sciences; (USA) Vol. 48:12; ISSN 0024-3205; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM AGENTS
DISEASES
DRUGS
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
MATERIALS
MEMBRANE PROTEINS
MITOCHONDRIA
NERVOUS SYSTEM DISEASES
ORGANIC COMPOUNDS
ORGANOIDS
PATHOGENESIS
PATIENTS
PROTEINS
PSYCHOTROPIC DRUGS
REACTION KINETICS
RECEPTORS
TRACER TECHNIQUES
TRANQUILIZERS
TRITIUM COMPOUNDS