Platelet peripheral benzodiazepine receptors in repeated stress

Journal Article · Tue Jan 01 04:00:00 EST 1991 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(91)90554-O· OSTI ID:5961885

Dar, D E; Bidder, M; Gavish, M ^[1]; Weizman, A; Karp, L; Tyano, S ^[2]; Grinshpoon, A; Bleich, A

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1. Technion-Israel Institute of Technology, Haifa (Israel)
2. Tel Aviv Univ. (Israel)

({sup 3}H)PK 11195 binding to platelet membranes and plasma stress hormones were studied in soldiers at the beginning of a parachute training course, following 6 days of preparatory exercises, and after the fourth actual parachute jump. A slight reduction (15%; NS) in the number of peripheral benzodiazepine receptors (PBR) was detected at the end of the exercise period, prior to the first jump. Reduced density of PBR was observed immediately after the repeated actual jumps. Equilibrium dissociation constants were not affected by the stressful situation. Plasma cortisol and prolactin levels remained unaltered during the entire study period.

• OSTI ID: 5961885
• Journal Information: Life Sciences; (USA), Journal Name: Life Sciences; (USA) Vol. 48:4; ISSN 0024-3205; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL STRESS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CELL CONSTITUENTS
CELL MEMBRANES
CORTICOSTEROIDS
DRUGS
GLUCOCORTICOIDS
GONADOTROPINS
HORMONES
HYDROCORTISONE
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KETONES
KINETICS
LTH
MATERIALS
MEMBRANE PROTEINS
MEMBRANES
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PITUITARY HORMONES
PREGNANES
PROTEINS
REACTION KINETICS
RECEPTORS
STEROIDS
SYMPATHOMIMETICS
SYNTHESIS
TRACER TECHNIQUES
TRITIUM COMPOUNDS