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Platelet alpha-2 adrenergic receptor-mediated phosphoinositide responses in endogenous depression

Journal Article · · Life Sciences; (USA)
 [1]; ;  [2]
  1. Municipal Second Hospital Otaru (Japan)
  2. Hokkaido Univ. School of Medicine, Sapporo (Japan)
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We have previously indicated that epinephrine stimulates phosphoinositide (PI) hydrolysis by activating alpha-2 adrenergic receptors in human platelets. This method involves the measurement of the accumulation of ({sup 3}H)-inositol-1-phosphate (IP-1) as an index of Pl hydrolysis; lithium is added to inhibit the metabolism of IP-1, thus giving an enhanced signal. In the present study, we assessed the platelet alpha-2 adrenergic receptor-mediated PI responses in samples from 15 unmedicated patients with endogenous depression and 15 age- and sex-matched control subjects. The responses to epinephrine in the depressed patients were significantly higher than those of the controls, whereas the basal values did not differ significantly. These results support the hypothesis that platelet alpha-2 adrenergic receptors may be supersensitive in patients with endogenous depression.

OSTI ID:
5915443
Journal Information:
Life Sciences; (USA), Journal Name: Life Sciences; (USA) Vol. 48:8; ISSN 0024-3205; ISSN LIFSA
Country of Publication:
United States
Language:
English

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Related Subjects

550201 -- Biochemistry-- Tracer Techniques
550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
DISEASES
DRUGS
ESTERS
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
LIPIDS
MATERIALS
MEMBRANE PROTEINS
METABOLISM
NERVOUS SYSTEM DISEASES
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PATHOGENESIS
PATIENTS
PHOSPHOLIPIDS
PROTEINS
REACTION KINETICS
RECEPTORS
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS