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Platelet alpha 2-adrenergic receptors in major depressive disorder. Binding of tritiated clonidine before and after tricyclic antidepressant drug treatment

Journal Article · · Arch. Gen. Psychiatr.; (United States)
; ; ; ;

The specific binding of tritiated (3H)-clonidine, an alpha 2-adrenergic receptor agonist, to platelet membranes was measured in normal subjects and in patients with major depressive disorder. The number of platelet alpha 2-adrenergic receptors from the depressed group was significantly higher than that found in platelets obtained from the control population. Treatment with tricyclic antidepressant drugs led to significant decreases in the number of platelet alpha 2-adrenergic receptors. These results support the hypothesis that the depressive syndrome is related to an alpha 2-adrenergic receptor supersensitivity and that the clinical effectiveness of tricyclic antidepressant drugs is associated with a decrease in the number of these receptors.

Research Organization:
Department of Pharmacology, The University of Michigan Medical School, Ann Arbor
OSTI ID:
5346543
Journal Information:
Arch. Gen. Psychiatr.; (United States), Journal Name: Arch. Gen. Psychiatr.; (United States) Vol. 38:12; ISSN ARGPA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL HORMONES
ADRENALINE
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM AGENTS
DRUGS
HORMONES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MATERIALS
MENTAL DISORDERS
NEUROREGULATORS
PATHOGENESIS
PATIENTS
PSYCHOTROPIC DRUGS
RECEPTORS
SENSITIVITY
STEROID HORMONES
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRANQUILIZERS
TRITIUM COMPOUNDS