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Depressed patients have decreased binding of tritiated imipramine to platelet serotonin ''transporter''

Journal Article · · Arch. Gen. Psychiatr.; (United States)
; ; ; ;

The high-affinity tritiated (3H) imipramine binding sites are functionally (and perhaps structurally) associated with the presynaptic neuronal and platelet uptake sites for serotonin. Since there is an excellent correlation between the relative potencies of a series of antidepressants in displacing 3H-imipramine from binding sites in human brain and platelet, we have examined the binding of 3H-imipramine to platelets from 14 depressed patients and 28 age- and sex-matched controls. A highly significant decrease in the number of 3H-imipramine binding sites, with no significant change in the apparent affinity constants, was observed in platelets from the depressed patients compared with the controls. These results, coupled with previous studies showing a significant decrease in the maximal uptake of serotonin in platelets from depressed patients, suggest that an inherited or acquired deficiency of the serotonin transport protein or proteins may be involved in the pathogenesis of depression.

Research Organization:
Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, MD
OSTI ID:
5466078
Journal Information:
Arch. Gen. Psychiatr.; (United States), Journal Name: Arch. Gen. Psychiatr.; (United States) Vol. 38:12; ISSN ARGPA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
ANTIDEPRESSANTS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZOLES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CENTRAL NERVOUS SYSTEM AGENTS
CHEMICAL BONDS
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMIPRAMINE
INDOLES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MATERIALS
MENTAL DISORDERS
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
PATIENTS
PROTEINS
PSYCHOTROPIC DRUGS
PYRROLES
RADIOPROTECTIVE SUBSTANCES
RECEPTORS
SEROTONIN
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TRYPTAMINES