Activation of the anticancer drug CCNU into a free radical intermediate via UV irradiation--an ESR study

Journal Article · Mon Jan 01 04:00:00 EST 1990 · Free Radical Biology and Medicine; (USA)

DOI:https://doi.org/10.1016/0891-5849(90)90019-F· OSTI ID:5913413

Raikov, Z D; Zheleva, A M; Raikova, E T ^[1]

---

1. Lab. of Molecular Oncology, Stara Zagora (Bulgaria)

We studied the formation of a free radical induced by UV irradiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in benzene. It was determined a stable nitroxide radical by ESR spectroscopy. We confirmed that sterically hindered cyclic amine 2,2,6,6-tetramethyl-4-piperidone (TMPone) was transformed into a corresponding stable free nitroxyl radical during UV irradiation. When CCNU was present, the rate of free radical formation from TMPone increased considerably.

• OSTI ID: 5913413
• Journal Information: Free Radical Biology and Medicine; (USA), Journal Name: Free Radical Biology and Medicine; (USA) Vol. 9:5; ISSN FRBME; ISSN 0891-5849
• Country of Publication: United States
• Language: English

Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTINEOPLASTIC DRUGS
AROMATICS
BENZENE
CHEMICAL RADIATION EFFECTS
CHEMISTRY
DRUGS
ELECTROMAGNETIC RADIATION
ELECTRON SPIN RESONANCE
HYDROCARBONS
MAGNETIC RESONANCE
ORGANIC COMPOUNDS
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATIONS
RADICALS
RADIOINDUCTION
RESONANCE
ULTRAVIOLET RADIATION