Enhancement of radiosensitizing effect of the nitroimidazole derivative RK28 on the proliferation of MethA tumor cells in combined use with diethyldithiocarbamate

Journal Article · Tue Jan 01 04:00:00 EST 1991 · Life Sciences; (United States)

DOI:https://doi.org/10.1016/0024-3205(91)90394-Q· OSTI ID:5906693

Mashiba, Harukazu; Matsunaga, Keiko; Hata, Kazuo ^[1]

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1. National Kyushu Cancer Center, Fukuoka (Japan)

The radiosensitizing effect of the nitroimidazole derivative RK28 and diethyldithiocarbamate (DDC), which is an inhibitor of superoxide dismutase activity, was examined in vitro by using Meth A tumor cells. The radiosensitizing effect of 0.5 mM RK28 was observed in both of 10 Gy and 15 Gy irradiated groups. The addition of 5 {times} 10{sup {minus}7} M DDC also enhanced the radiation-induced proliferation inhibition. Marked enhancement of the anti-proliferative effect was observed in combined use of 0.2 mM or 0.5 mM RK28 with 2 {times} 10 M or 5 {times} 10{sup {minus}7} M DDC. These results suggest that enhanced oxygen effect could be expected through combined use of the ionizing irradiation with both of these agents.

• OSTI ID: 5906693
• Journal Information: Life Sciences; (United States), Journal Name: Life Sciences; (United States) Vol. 49:19; ISSN 0024-3205; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
AZOLES
CELL PROLIFERATION
ENZYME INHIBITORS
ENZYMES
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDOREDUCTASES
PROTEINS
RADIOSENSITIVITY EFFECTS
SUPEROXIDE DISMUTASE
TUMOR CELLS