Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae

Journal Article · Fri May 01 04:00:00 EDT 1987 · Genetics; (United States)

OSTI ID:5899309

Rine, J; Herskowitz, I

Mating type interconversion in Saccharomyces cerevisiae occurs by transposition of copies of the a or ..cap alpha.. mating type cassettes from inactive loci, HML and HMR, to an active locus, MAT. The lack of expression of the a and ..cap alpha.. genes at the silent loci results from repression by trans-acting regulators encoded by SIR (Silent Information Regulator) genes. In this paper the authors present evidence for the existence of four SIR genes. Inactivation of any of these genes leads to expression of cassettes at both HML and HMR. Unusual complementation properties are observed for a number of sir mutations. Specifically, some recessive mutations in different genes fail to complement. The correspondence between SIR1, SIR2, SIR3, SIR4 and other genes with similar roles (MAR, CMT, STE8 and STE9) is presented.

• Research Organization: Univ. of Oregon, Eugene
• OSTI ID: 5899309
• Journal Information: Genetics; (United States), Journal Name: Genetics; (United States) Vol. 116:1; ISSN GENTA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
FUNGI
GENES
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
INACTIVATION
MICROORGANISMS
MUTAGENESIS
MUTATION FREQUENCY
MUTATIONS
PLANTS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RECESSIVE MUTATIONS
SACCHAROMYCES
SACCHAROMYCES CEREVISIAE
ULTRAVIOLET RADIATION
YEASTS