Mechanism of solute retention in supercritical fluid chromatography

Conference · Thu Feb 28 23:00:00 EST 1985

OSTI ID:5897015

Yonker, C R; Smith, R D; Wright, B W

Retention in supercritical fluid chromatography (SFC) is determined by solute solubility in the fluid and solute interaction with the stationary phase. The functional relationship between retention and pressure at constant temperature has been described by Van Wasen and Schneider. The trend in retention is shown to depend on the partial molar volume of the solute in the mobile and stationary phase coupled with the isothermal compressibility of the fluid mobile phase. The purpose of this work was to determine the relationship between solubility and retention. A thermodynamic model was developed which predicts the trend in retention as a function of pressure, given the solubility of the solute in the fluid mobile phase. From this model, solute retention behavior can be examined by theory and experiment in order to gain some insight into the complicated dependence of retention on the thermodynamic and physical properties of the solute and the fluid, providing a basis for consideration of more subtle effects unique to SFC. 15 refs., 2 figs.

• Research Organization: Pacific Northwest Lab., Richland, WA (USA)
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 5897015
• Report Number(s): PNL-SA-12937; CONF-850942-55; ON: DE86011325
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400102* -- Chemical & Spectral Procedures
AROMATICS
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CHALCOGENIDES
CHROMATOGRAPHY
COMPRESSIBILITY
CONDENSED AROMATICS
EQUATIONS
EQUATIONS OF STATE
HYDROCARBONS
MATHEMATICAL MODELS
MECHANICAL PROPERTIES
NAPHTHALENE
ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PHYSICAL PROPERTIES
PRESSURE DEPENDENCE
RETENTION
SEPARATION PROCESSES
SOLUBILITY
SOLUTES
SUPERCRITICAL FLUID CHROMATOGRAPHY
THERMODYNAMIC PROPERTIES