Effect of LET and microdistribution of radiation on the transformation in vitro and in vivo

Technical Report · Thu Sep 01 04:00:00 EDT 1983

DOI:https://doi.org/10.2172/5896152· OSTI ID:5896152

Little, J. B.

The objective is to learn more about the mechanisms which determine the carcinogenic effects of ionizing radiation, particularly as they relate to high LET radiation exposure. The approach is an in vitro one, involving the study of malignant transformation and the induction of specific gene mutations in mammalian cells. The study was focused on the basic characteristics of alpha radiation transformation in vitro. A particular goal was to evaluate the relative effectiveness of focal vs diffuse irradiation in the induction of transformation. More emphasis was placed on the study of mechanisms of radiation carcinogenesis by studying the events evolved in the process of radiation-induced malignant transformation. This included an investigation of the effects of non-carcinogenic secondary factors and promoting agents on radiation transformation in vitro. We also propose at this time to initiate the studies of the effects of Auger electron-emitting radionuclides as another approach to the examination of the role of the distribution of radiant energy within cells and tissues.

• Research Organization: Harvard Univ., Boston, MA (USA). School of Public Health
• DOE Contract Number: AC02-77EV04322
• OSTI ID: 5896152
• Report Number(s): DOE/EV/04322-T3; ON: DE83017450
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALPHA PARTICLES
ANIMAL CELLS
ANIMALS
CARCINOGENESIS
CHARGED PARTICLES
ENERGY TRANSFER
GENE MUTATIONS
IN VITRO
LET
MAMMALS
MICE
MUTATIONS
ONCOGENIC TRANSFORMATIONS
PATHOGENESIS
RADIOINDUCTION
RODENTS
VERTEBRATES