Effect of LET and microdistribution of radiation on the transformation in vitro and in vivo. Comprehensive progress report

Technical Report · Thu Sep 01 04:00:00 EDT 1983

DOI:https://doi.org/10.2172/5895948· OSTI ID:5895948

Little, J. B.

Work has involved the following three areas: (1) an investigation of the mechanisms of radiation carcinogenesis by studying the events involved in the process of malignant transformation of mouse 10 T-1/2 cells; (2) an investigation of the effects of promoting agents on radiation-induced transformation in vitro; and (3) an investigation of the induction of transformation by internally emitting radionuclides incorporated into cellular DNA. The latter area has been extended to include studies of mutagenesis by these radionuclides in human lymphoblasts, and molecular measurements of DNA strand breaks. During the past year, research has focused on the first area, as well as on studies of the mutagenic effects of incorporated radionuclides.

• Research Organization: Harvard Univ., Boston, MA (USA). School of Public Health
• DOE Contract Number: AC02-77EV04322
• OSTI ID: 5895948
• Report Number(s): DOE/EV/04322-T2; ON: DE83017429
• Country of Publication: United States
• Language: English

Related Subjects

560122* -- Radiation Effects on Cells-- Internal Source-- (-1987)
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CARCINOGENESIS
CELL CULTURES
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
IN VITRO
INTERMEDIATE MASS NUCLEI
INTERNAL IRRADIATION
IODINE 125
IODINE ISOTOPES
IRRADIATION
ISOTOPES
MAMMALS
MICE
MUTAGENESIS
NUCLEI
ODD-EVEN NUCLEI
ONCOGENIC TRANSFORMATIONS
PATHOGENESIS
PROMOTERS
RADIOINDUCTION
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RODENTS
STRAND BREAKS
TUMOR PROMOTERS
VERTEBRATES