In vivo evaluation of experimental myocardial infarcts by ungated computed tomography
The potential of ungated computed tomography to detect and quantify myocardial infarctions was assessed in 10 dogs. Twenty-seven in vivo CT examinations were performed at various time intervals after coronary artery occlusion. After intravenous contrast administration, CT delineated the infarcted myocardium in all 27 studies. The CT-determined infarct volume before sacrifice was closely correlated with the postmortem infarct weight. Delayed accumulation of iodinated contrast material in the infarct was seen in all 22 examinations performed 3 1/2 hr or longer postocclusion. The dynamics of contrast material accumulation and disappearance from normal and ischemic myocardium were also assessed. Presently available CT scanning without gating can noninvasively detect and quantify myocardial infarctions of various sizes and ages in living animals and can evaluate contrast dynamics whose time course is greater than a single circulation time.
- OSTI ID:
- 5877844
- Journal Information:
- AJR, Am. J. Roentgenol.; (United States), Vol. 136:3
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
HEART
COMPUTERIZED TOMOGRAPHY
MYOCARDIAL INFARCTION
DIAGNOSIS
CORONARIES
DIAGNOSTIC USES
DOGS
IN VIVO
ISCHEMIA
PATHOLOGY
RADIONUCLIDE KINETICS
ANIMALS
ARTERIES
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DIAGNOSTIC TECHNIQUES
DISEASES
MAMMALS
ORGANS
TOMOGRAPHY
USES
VASCULAR DISEASES
VERTEBRATES
550603* - Medicine- External Radiation in Therapy- (1980-)
551001 - Physiological Systems- Tracer Techniques
550901 - Pathology- Tracer Techniques