In vivo evaluation of experimental myocardial infarcts by ungated computed tomography
The potential of ungated computed tomography to detect and quantify myocardial infarctions was assessed in 10 dogs. Twenty-seven in vivo CT examinations were performed at various time intervals after coronary artery occlusion. After intravenous contrast administration, CT delineated the infarcted myocardium in all 27 studies. The CT-determined infarct volume before sacrifice was closely correlated with the postmortem infarct weight. Delayed accumulation of iodinated contrast material in the infarct was seen in all 22 examinations performed 3 1/2 hr or longer postocclusion. The dynamics of contrast material accumulation and disappearance from normal and ischemic myocardium were also assessed. Presently available CT scanning without gating can noninvasively detect and quantify myocardial infarctions of various sizes and ages in living animals and can evaluate contrast dynamics whose time course is greater than a single circulation time.
- OSTI ID:
- 5877844
- Journal Information:
- AJR, Am. J. Roentgenol.; (United States), Journal Name: AJR, Am. J. Roentgenol.; (United States) Vol. 136:3; ISSN AAJRD
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ARTERIES
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
CORONARIES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DOGS
HEART
IN VIVO
ISCHEMIA
MAMMALS
MYOCARDIAL INFARCTION
ORGANS
PATHOLOGY
RADIONUCLIDE KINETICS
TOMOGRAPHY
USES
VASCULAR DISEASES
VERTEBRATES