Magnetic resonance imaging and spectroscopy of intraocular tumors

Journal Article · Mon May 01 00:00:00 EDT 1989 · Surv. Ophthamol.; (United States)

DOI:https://doi.org/10.1016/0039-6257(89)90052-0· OSTI ID:5877526

Kolodny, N H; Gragoudas, E S; D'Amico, D J; Albert, D M

Proton magnetic resonance imaging (/sup 1/H MRI) has emerged as a clinically useful tool for the diagnosis of intraocular tumors. During the last four years 1H MRI characteristics, including spin-lattice relaxation times (T1) and spin-spin relaxation times (T2), have been established for several types of tumors. The introduction of surface coils to the imaging process has significantly improved the quality of intraocular MR images, leading some clinicians to suggest that 1H MR images are preferable to CT scans. Another MRI technique, in which sodium-23 (/sup 23/Na) is imaged rather than protons, is now under development as tool for intraocular diagnosis. The potential of /sup 23/Na MRI depends upon the high concentration and visibility of sodium in the vitreous body, and upon the apparent differences in sodium behavior in normal cells vs. tumor cells. The metabolism of normal ocular tissues and intraocular tumors may be probed noninvasively with phosphorus-31 MR spectroscopy (/sup 31/P MRS). Much progress has been made during the last few years in understanding the appearance of /sup 31/P MR spectra of many types of healthy and diseased cells and tissues. Clinical application of this technique to the diagnosis and monitoring of intraocular tumors following conservative treatment will be dependent upon the development of spectroscopy techniques that collect information from the volume of interest (tumor) only. 54 references.

• Research Organization: Massachusetts Eye and Ear Infirmary, Boston (USA)
• OSTI ID: 5877526
• Journal Information: Surv. Ophthamol.; (United States), Journal Name: Surv. Ophthamol.; (United States) Vol. 33:6; ISSN SUOPA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALI METAL ISOTOPES
BARYONS
BODY
BODY AREAS
CELL CONSTITUENTS
CELL NUCLEI
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DOCUMENT TYPES
ELEMENTARY PARTICLES
EYES
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FERMIONS
HADRONS
HEAD
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LIGHT NUCLEI
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NEOPLASMS
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NUCLEAR MAGNETIC RESONANCE
NUCLEI
NUCLEONS
ODD-EVEN NUCLEI
OPTIMIZATION
ORGANS
PHOSPHORUS 31
PHOSPHORUS ISOTOPES
PROTONS
RESONANCE
REVIEWS
SENSE ORGANS
SODIUM 23
SODIUM ISOTOPES
STABLE ISOTOPES