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Title: Intraocular radiation blocking

Abstract

Iodine-based liquid radiographic contrast agents were placed in normal and tumor-bearing (Greene strain) rabbit eyes to evaluate their ability to block iodine-125 radiation. This experiment required the procedures of tumor implantation, vitrectomy, air-fluid exchange, and 125I plaque and thermoluminescent dosimetry (TLD) chip implantation. The authors quantified the amount of radiation attenuation provided by intraocularly placed contrast agents with in vivo dosimetry. After intraocular insertion of a blocking agent or sham blocker (saline) insertion, episcleral 125I plaques were placed across the eye from episcleral TLD dosimeters. This showed that radiation attenuation occurred after blocker insertion compared with the saline controls. Then computed tomographic imaging techniques were used to describe the relatively rapid transit time of the aqueous-based iohexol compared with the slow transit time of the oil-like iophendylate. Lastly, seven nontumor-bearing eyes were primarily examined for blocking agent-related ocular toxicity. Although it was noted that iophendylate induced intraocular inflammation and retinal degeneration, all iohexol-treated eyes were similar to the control eyes at 7 and 31 days of follow-up. Although our study suggests that intraocular radiopaque materials can be used to shield normal ocular structures during 125I plaque irradiation, a mechanism to keep these materials from exiting the eye must be devisedmore » before clinical application.« less

Authors:
; ; ; ; ; ;  [1]
  1. (North Shore Univ. Hospital, Manhasset, NY (USA))
Publication Date:
OSTI Identifier:
6141673
Resource Type:
Journal Article
Resource Relation:
Journal Name: Investigative Ophthalmology and Visual Science; (USA); Journal Volume: 31:9
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CONTRAST MEDIA; RADIOSENSITIVITY EFFECTS; EYES; EXPERIMENTAL NEOPLASMS; COMPUTERIZED TOMOGRAPHY; IODINE 125; RABBITS; THERMOLUMINESCENT DOSIMETRY; ANIMALS; BETA DECAY RADIOISOTOPES; BODY; BODY AREAS; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DOSIMETRY; ELECTRON CAPTURE RADIOISOTOPES; FACE; HEAD; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; SENSE ORGANS; TOMOGRAPHY; VERTEBRATES; 550603* - Medicine- External Radiation in Therapy- (1980-)

Citation Formats

Finger, P.T., Ho, T.K., Fastenberg, D.M., Hyman, R.A., Stroh, E.M., Packer, S., and Perry, H.D.. Intraocular radiation blocking. United States: N. p., 1990. Web.
Finger, P.T., Ho, T.K., Fastenberg, D.M., Hyman, R.A., Stroh, E.M., Packer, S., & Perry, H.D.. Intraocular radiation blocking. United States.
Finger, P.T., Ho, T.K., Fastenberg, D.M., Hyman, R.A., Stroh, E.M., Packer, S., and Perry, H.D.. Sat . "Intraocular radiation blocking". United States. doi:.
@article{osti_6141673,
title = {Intraocular radiation blocking},
author = {Finger, P.T. and Ho, T.K. and Fastenberg, D.M. and Hyman, R.A. and Stroh, E.M. and Packer, S. and Perry, H.D.},
abstractNote = {Iodine-based liquid radiographic contrast agents were placed in normal and tumor-bearing (Greene strain) rabbit eyes to evaluate their ability to block iodine-125 radiation. This experiment required the procedures of tumor implantation, vitrectomy, air-fluid exchange, and 125I plaque and thermoluminescent dosimetry (TLD) chip implantation. The authors quantified the amount of radiation attenuation provided by intraocularly placed contrast agents with in vivo dosimetry. After intraocular insertion of a blocking agent or sham blocker (saline) insertion, episcleral 125I plaques were placed across the eye from episcleral TLD dosimeters. This showed that radiation attenuation occurred after blocker insertion compared with the saline controls. Then computed tomographic imaging techniques were used to describe the relatively rapid transit time of the aqueous-based iohexol compared with the slow transit time of the oil-like iophendylate. Lastly, seven nontumor-bearing eyes were primarily examined for blocking agent-related ocular toxicity. Although it was noted that iophendylate induced intraocular inflammation and retinal degeneration, all iohexol-treated eyes were similar to the control eyes at 7 and 31 days of follow-up. Although our study suggests that intraocular radiopaque materials can be used to shield normal ocular structures during 125I plaque irradiation, a mechanism to keep these materials from exiting the eye must be devised before clinical application.},
doi = {},
journal = {Investigative Ophthalmology and Visual Science; (USA)},
number = ,
volume = 31:9,
place = {United States},
year = {Sat Sep 01 00:00:00 EDT 1990},
month = {Sat Sep 01 00:00:00 EDT 1990}
}