Enhanced tumor development by butylated hydroxytoluene (BHT) in liver, lung and gastrointestinal tract

Conference · Wed Apr 02 23:00:00 EST 1986

OSTI ID:5876771

Witschi, H P

Continuous feeding of 0.5% or 0.05% of butylated hydroxytoluene (BHT) enhances the development of spontaneously occurring liver tumors in C3H mice, but not in BALB/c mice. In mouse lung, the tumor-enhancing effects of BHT vary with the carcinogen used and in the gastrointestinal tract of mice and rats BHT enhances development of dimethylhydrazine-induced tumors but is without effect on tumors produced by methylnitrosourea. Strain differences, effect upon various carcinogens, paradoxical dose-responses and mechanisms of action remain major questions in the toxicology of BHT. 14 refs., 2 tabs.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 5876771
• Report Number(s): CONF-8604155-1; ON: TI86009149
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIOXIDANTS
AROMATICS
BODY
CARCINOGENESIS
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
GLANDS
HYDROXY COMPOUNDS
LIVER
MAMMALS
MICE
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PHENOLS
PROMOTERS
RATS
RODENTS
SPECIES DIVERSITY
TUMOR PROMOTERS
VERTEBRATES