Sensitivity of bronchoprovocation and tracheal mucous velocity in detecting airway responses to O3. [Sheep]

Journal Article · Thu May 01 00:00:00 EDT 1980 · J. Appl. Physiol.; (United States)

OSTI ID:5875874

Abraham, W M; Januszkiewicz, A J; Mingle, M; Welker, M; Wanner, A; Sackner, M A

This study was undertaken to determine whether measurements of tracheal mucous velocity or airway reactivity to inhaled carbachol more sensitively detect airway effects of inhaled ozone (O3) in conscious sheep. Dose-response curves of mean pulmonary flow resistance (RL) to carbachol were obtained by measuring RL after five breaths of carbachol aerosol with stepwise increases in drug concentration. The animals then breathed 0.5 ppM O3 through an endotracheal tube for 2 h. The dose-response curves were repeated immediately after the 0.5 ppM O3 exposure and 24 h later. In conscious sheep, airway hyperreactivity appears to be a more sensitive indicator of airway effects produced by short-term exposure to 0.5 ppM O3 than depression of tracheal mucous velocity.

• OSTI ID: 5875874
• Journal Information: J. Appl. Physiol.; (United States), Journal Name: J. Appl. Physiol.; (United States) Vol. 48:5; ISSN JAPYA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ALCOHOLS
ANIMALS
BIOLOGICAL EFFECTS
COLLOIDS
DISPERSIONS
DOMESTIC ANIMALS
DOSE-RESPONSE RELATIONSHIPS
HYDROXY COMPOUNDS
INHALATION
INTAKE
MAMMALS
MEMBRANES
MUCOUS MEMBRANES
ORGANIC COMPOUNDS
OZONE
PHARMACOLOGY
PHYSIOLOGY
RESPIRATORY SYSTEM
RUMINANTS
SHEEP
SOLS
TRACHEA
VERTEBRATES