Differences in airway reactivity in normal and allergic sheep after exposure to sulfur dioxide
The effect of breathing 5 ppm sulfur dioxide (SO/sub 2/) on airway reactivity was studied in both normal and allergic conscious sheep. Allergic sheep were defined as animals in which inhalation of Axcaris suum extract resulted in bronchospasm as evidenced by an increase in mean pulmonary flow resistance (RL), hyperinflation, and a fall in dynamic compliance. Airway reactivity was assessed by measuring the increase of RL after 18 breaths of 0.25% carbachol (c), from an initial RL value obtained after 18 breaths of buffered saline (s) (RL(c-s)). RL and RL(c-s) were determined prior to, immediately after, and 24 h after exposure to 5 ppm SO/sub 2/ for 4 h. In both groups RL remained unchanged after SO/sub 2/ exposure. Prior to exposure, RL(c-s) was not significantly different in seven normal (0.3 +/- 0.1) and seven allergic sheep (0.4 +/- 0.2 (SD) cmH/sub 2/O.l/sup -1/.s), and there was no significant change in RL (c-s) immediately after SO/sub 2/ exposure in either group. Twenty-four h later, RL(c-s) RL(c-s) increased to 0.7 +/- 0.8 (P < 0.2) in normal and to 1.8 +/- 0.9 cmH/sub 2/O.l/sup -1/.s (P < 0.01) in allergic sheep. Because the increase in RL(c-s) after 24 h was greater (P < 0.01) in allergic than in normal sheep, we conclude that SO/sub 2/ exposure increased airway reactivity more in the former than in the latter.
- Research Organization:
- Mount Sinai Medical Center, Miami Beach, FL
- OSTI ID:
- 5428786
- Journal Information:
- J. Appl. Physiol.; (United States), Journal Name: J. Appl. Physiol.; (United States) Vol. 51:6; ISSN JAPYA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ALLERGY
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL STRESS
BODY
BREATH
CHALCOGENIDES
DISEASES
DOMESTIC ANIMALS
EPIDEMIOLOGY
LUNGS
MAMMALS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
POLLUTION
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RUMINANTS
SHEEP
SULFUR COMPOUNDS
SULFUR DIOXIDE
SULFUR OXIDES
VERTEBRATES