Regional variations in pulmonary alveolar/epithelial (A/V) permeability in smokers studied with Tc-99m-DTPA aerosol

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5873696

Min, L K; Griffith, D; Brown, P H; Turner, F E; Mueller, D; Johnson, R; Krishnamurthy, G T; Holden, W; Morris, J

Many diseases affecting the lung show regional preferences. The effect of smoking on the upper and lower lung A/V permeability was studied in 6 smokers and 11 controls. The subject inhaled Tc-99m-DTPA aerosol (Synaco Nebulizer) in a sitting position for 3 minutes to achieve a dose rate of 2 mr/hr as measured by a Geiger counter on the dorsal surface of the chest. The posterior lung images in supine position were later obtained using an LFOV gamma camera and the MDS computer. The clearance half times for the upper and lower areas of each lung were calculated for 0-20 minutes and the results were tested by paired t-test. The results suggest that there are significant differences in the pulmonary A/V permeability between upper and lower regions in smokers while there are none in controls, implying possibly a more pronounced damaging effect of smoking in the upper lung fields. The regional differences should be taken into account while studying various pulmonary pathology with Tc-99m-DTPA aerosol.

• Research Organization: VA Medical Center
• OSTI ID: 5873696
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

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550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AEROSOLS
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COLLOIDS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISPERSIONS
DOSES
DRUGS
DTPA
EXCRETION
HAZARDS
HEALTH HAZARDS
HOURS LIVING RADIOISOTOPES
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLING
LUNG CLEARANCE
LUNGS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGY
RADIATION DOSES
RADIOACTIVE AEROSOLS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPROTECTIVE SUBSTANCES
RESIDUES
RESPIRATORY SYSTEM
SCINTISCANNING
SMOKES
SOLS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TOBACCO SMOKES
UPTAKE
USES
YEARS LIVING RADIOISOTOPES