Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Effect of misonidazole therapy on human granulopoietic stem cells

Journal Article · · Cancer Treat. Rep.; (United States)
OSTI ID:5871773
; ; ;
Misonidazole is a 2 nitroimidazole compound currently being assessed as a radiosensitizing agent. The effects of misonidazole on human bone marrow hematopoiesis were assayed by culture of committed granulocyte-macrophage progenitor cells (CFU-C). Three groups of patients with nonhematologic malignancies were selected for study. The first group of patients received a single, large dose of misonidazole; the second group received smaller, multiple doses of misonidazole; and the third group who did not receive any misonidazole served as irradiation controls. In 14 of 16 patients who received single or multiple doses of misonidazole, there was a significant decrease in the number of CFU-C present in the bone marrow after misonidazole therapy. In five patients who received irradiation only, there was no difference in the number of pre- and post-treatment bone marrow CFU-C. In misonidazole treated patients, extensive washing of post-treatment bone marrow samples failed to return CFU-C growth to control values. Suppression of CFU-C growth persisted for 3 weeks and returned to control values by 8 weeks. This reduction in the proliferative capacity of human bone marrow progenitor cells suggests that misonidazole may add to the myelotoxicity already associated with radiotherapy, systemic chemotherapy, or as combination of the two.
OSTI ID:
5871773
Journal Information:
Cancer Treat. Rep.; (United States), Journal Name: Cancer Treat. Rep.; (United States) Vol. 64:10-11; ISSN CTRRD
Country of Publication:
United States
Language:
English

Similar Records

Myelotoxicity induced in female B6C3F1 mice by inhalation of methyl isocyanate
Journal Article · Mon Jun 01 00:00:00 EDT 1987 · Environ. Health Perspect.; (United States) · OSTI ID:6061182
Cytotoxic and radiosensitizing effects of misonidazole on hematopoiesis in normal and tumor-bearing mice. [/sup 137/Cs]
Conference · Mon Sep 01 00:00:00 EDT 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States) · OSTI ID:7056717
Identification of a hypoxic population of bone marrow cells
Journal Article · Mon Jan 31 23:00:00 EST 1983 · Int. J. Radiat. Oncol., Biol. Phys.; (United States) · OSTI ID:5502552

Related Subjects

550300 -- Cytology
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
560151 -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANTINEOPLASTIC DRUGS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD FORMATION
BODY
BONE MARROW
CFU
DRUGS
FRACTIONATED IRRADIATION
HEMATOPOIETIC SYSTEM
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IRRADIATION
MISONIDAZOLE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATIENTS
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
SOMATIC CELLS
STEM CELLS
TISSUES