Cytotoxic and radiosensitizing effects of misonidazole on hematopoiesis in normal and tumor-bearing mice. [/sup 137/Cs]

Conference · Mon Sep 01 04:00:00 EDT 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:7056717

Turner, A R; Allalunis, M J; Urtasun, R C; Pedersen, J E; Meeker, B E

Misonidazole is a 2-nitroimidazole hypoxic cell radiosensitizing agent currently undergoing clinical trials. Preliminary studies have shown that misonidazole is toxic to human hematopoietic stem cells. A survey of the effects of misonidazole on a variety of murine hematopoietic stemcells was undertaken. No cytotoxicity or radiosensitization could be demonstrated when misonidazole was administered in vivo. Misonidazole was toxic to bone marrow when incubated in vitro in liquid cultures for long periods at higher concentrations than that attainable in vivo. CFU-C proliferation was also assessed in animals bearing Lewis lung tumor. These studies indicate that misonidazole is not toxic to murine hematopoiesis in vivo, but there are indications that it may be toxic in situations in which relatively high concentrations are maintained for long periods of time.

• Research Organization: Cross Cancer Inst. and Univ. of Alberta, Canada
• OSTI ID: 7056717
• Conference Information: Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 6:9
• Country of Publication: United States
• Language: English

Related Subjects

560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
ANOXIA
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD FORMATION
BODY
BONE MARROW
CESIUM 137
CESIUM ISOTOPES
CFU
COLONY FORMATION
DATA
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
GAMMA RADIATION
HEMATOPOIETIC SYSTEM
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IN VITRO
IN VIVO
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
LUNGS
MAMMALS
MICE
NEOPLASMS
NITRO COMPOUNDS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
RODENTS
SPLEEN COLONY FORMATION
SUBLETHAL IRRADIATION
TISSUES
TUMOR CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES