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Radiosensitization of tumors and normal tissues by combined treatment with misonidazole and heat

Journal Article · · Radiology; (United States)
; ; ; ;
Combination treatment of mice with misonidazole (0.5 mg/g body wt.) and hyperthermia (41.4 degrees C for 45 mins.) produced dramatic radiosensitization in hypoxic BP-8 murine sarcoma cells. The dose modifying factory (DMF: 4.3) was such that hypoxic BP-8 cells subjected to combination therapy became more radiosensitive than untreated, fully oxygenated cell populations. In contrast, radiosensitization by combination treatment was comparatively minor or completely absent in normal body tissues such as skin (DMF: 1.57), intestine (DMF: 1.0), and bone marrow (DMF: 1.0). These results suggest that simultaneous administration of misonidazole and hyperthermia may prove an effective adjuvant to conventional clinical radiation therapy.
Research Organization:
Institute of Molecular Biophysics, Florida State University, Tallahassee
OSTI ID:
5388793
Journal Information:
Radiology; (United States), Journal Name: Radiology; (United States) Vol. 141:3; ISSN RADLA
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
ANOXIA
ANTINEOPLASTIC DRUGS
AZOLES
BODY
BODY TEMPERATURE
BONE MARROW
DIGESTIVE SYSTEM
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DRUGS
GASTROINTESTINAL TRACT
HEMATOPOIETIC SYSTEM
HETEROCYCLIC COMPOUNDS
HYPERTHERMIA
IMIDAZOLES
INTESTINES
MAMMALS
MEDICINE
MICE
MISONIDAZOLE
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIOLOGY
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
RODENTS
SARCOMAS
SKIN
THERAPY
TISSUES
TUMOR CELLS
VERTEBRATES