Radiosensitization of tumors and normal tissues by combined treatment with misonidazole and heat

Journal Article · Tue Dec 01 04:00:00 EST 1981 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.141.3.7302238· OSTI ID:5796507

Hofer, K G; MacKinnon, A R; Schubert, A L; Lehr, J E; Grimmett, E V

Combination treatment of mice with misonidazole (0.5 mg/g body wt.) and hyperthermia (41.5/sup o/C for 45 mins.) produced dramatic radiosensitization in hypoxic BP-8 murine sarcoma cells. The dose modifying factor (DMF: 4.3) was such that hypoxic BP-8 cells subjected to combination therapy became more radiosensitive than untreated, fully oxygenated cell populations. In contrast, radiosensitization by combination treatment was comparatively minor or completely absent in normal body tissues such as skin (DMF: 1.57), intestine (DMF: 1.0), and bone marrow (DMF: 1.0). These results suggest that simultaneous administration of misonidazole and hyperthermia may prove an effective adjuvant to conventional clinical radiation therapy.

• Research Organization: Florida State Univ., Tallahassee
• OSTI ID: 5796507
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 141:3; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
AZOLES
DISEASES
DRUGS
HETEROCYCLIC COMPOUNDS
MAMMALS
MEDICINE
MICE
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIOLOGY
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
RODENTS
SARCOMAS
THERAPY
THIADIAZOLES
VERTEBRATES