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Title: Revision of gonadal radiation dose to man from thallium-201

Abstract

Thallium-201 as thallous chloride is now routinely used for myocardial imaging. We observed a biological translocation of T1-201 leading to a gradual increase in the concentration of radioactivity in the testes which facilitated testicular imaging. The initial distribution of intravenously injected tracer dose is greatly dependent on the distribution of cardiac output, but its metabolic fate is analogous to the potassium ion. We have extensively studied the kinetics of thallium in rats, and also carried out limited comparative studies in different species. An attempt was also made to compare the uptake values that could be obtained in dogs by quantitative imaging and by autopsy. Separation of scrotum, epididymis and testes revealed that the increase in uptake occurred predominantly in the testes. The uptake increased with time for about 1 day, and after 2 days it declined with a biological half-life of approximately 2 days. The later phase of testicular clearance was similar to the rate of clearance from other organs. The testicular uptake of T1-201 was highest in rats: the initial value at 10 to 15 min was 0.48 +- 0.09% of the injected dose which increased to 1.77 +- 0.20% by 1 day. The initial uptake in mice wasmore » low (0.18 +- 0.06%) but it increased to about 4 folds by 1 day. Values in human, extrapolated from limited quantitative imaging, was similar to mice. These studies indicated the need for the revision of the gonadal radiation dose to man. Calculations show, contrary to the accepted value of about 0.5 rads/mCi, an approximate value of 1.5 rads/mCi is more realistic.« less

Authors:
;
Publication Date:
Research Org.:
Univ. of Texas, Houston
OSTI Identifier:
5870050
Report Number(s):
CONF-801082-
Journal ID: CODEN: HPFSD; TRN: 82-003970
Resource Type:
Conference
Journal Name:
HHS Publ. (FDA) (U.S.); (United States)
Additional Journal Information:
Journal Volume: 81-8166; Conference: ORAU radiopharmaceutical dosimetry symposium, Oak Ridge, TN, USA, 6 Oct 1980
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; TESTES; BIOLOGICAL RADIATION EFFECTS; THALLIUM 201; BIOLOGICAL LOCALIZATION; DIAGNOSTIC USES; DOSIMETRY; EXTRAPOLATION; LABORATORY ANIMALS; MYOCARDIUM; PATIENTS; RADIATION DOSE DISTRIBUTIONS; RADIATION DOSES; RADIONUCLIDE KINETICS; SCINTISCANNING; SIDE EFFECTS; THALLIUM CHLORIDES; BETA DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BODY; CARDIOVASCULAR SYSTEM; CHLORIDES; CHLORINE COMPOUNDS; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DOSES; ELECTRON CAPTURE RADIOISOTOPES; GONADS; HALIDES; HALOGEN COMPOUNDS; HEART; HEAVY NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MALE GENITALS; MUSCLES; NUCLEI; NUMERICAL SOLUTION; ODD-EVEN NUCLEI; ORGANS; RADIATION EFFECTS; RADIOISOTOPE SCANNING; RADIOISOTOPES; SECONDS LIVING RADIOISOTOPES; THALLIUM COMPOUNDS; THALLIUM ISOTOPES; USES; 560171* - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987); 560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987); 560161 - Radionuclide Effects, Kinetics, & Toxicology- Man; 550601 - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Hosain, P., and Hosain, F. Revision of gonadal radiation dose to man from thallium-201. United States: N. p., 1981. Web.
Hosain, P., & Hosain, F. Revision of gonadal radiation dose to man from thallium-201. United States.
Hosain, P., and Hosain, F. Mon . "Revision of gonadal radiation dose to man from thallium-201". United States.
@article{osti_5870050,
title = {Revision of gonadal radiation dose to man from thallium-201},
author = {Hosain, P. and Hosain, F.},
abstractNote = {Thallium-201 as thallous chloride is now routinely used for myocardial imaging. We observed a biological translocation of T1-201 leading to a gradual increase in the concentration of radioactivity in the testes which facilitated testicular imaging. The initial distribution of intravenously injected tracer dose is greatly dependent on the distribution of cardiac output, but its metabolic fate is analogous to the potassium ion. We have extensively studied the kinetics of thallium in rats, and also carried out limited comparative studies in different species. An attempt was also made to compare the uptake values that could be obtained in dogs by quantitative imaging and by autopsy. Separation of scrotum, epididymis and testes revealed that the increase in uptake occurred predominantly in the testes. The uptake increased with time for about 1 day, and after 2 days it declined with a biological half-life of approximately 2 days. The later phase of testicular clearance was similar to the rate of clearance from other organs. The testicular uptake of T1-201 was highest in rats: the initial value at 10 to 15 min was 0.48 +- 0.09% of the injected dose which increased to 1.77 +- 0.20% by 1 day. The initial uptake in mice was low (0.18 +- 0.06%) but it increased to about 4 folds by 1 day. Values in human, extrapolated from limited quantitative imaging, was similar to mice. These studies indicated the need for the revision of the gonadal radiation dose to man. Calculations show, contrary to the accepted value of about 0.5 rads/mCi, an approximate value of 1.5 rads/mCi is more realistic.},
doi = {},
journal = {HHS Publ. (FDA) (U.S.); (United States)},
number = ,
volume = 81-8166,
place = {United States},
year = {1981},
month = {6}
}

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