Uptake of Tl-201 in the testes: Implications for radiation dosimetry

Journal Article · Mon May 01 04:00:00 EDT 1995 · Journal of Nuclear Medicine

OSTI ID:441606

Stabin, M G ^[1]; Thomas, S R ^[2]; Wilson, R A ^[3]

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1. Oak Ridge Inst. for Science and Education, TN (United States)
2. Univ. of Cincinnati, OH (United States)
3. Oregon Health Sciences Univ., Portland, OR (United States); and others

The radiation dose to the testes from Tl-201 chloride has been an outstanding question for a number of years. Previous studies have presented kinetic data for the testes with percentage uptake ranging over nearly an order of magnitude from 0.15% to 1.2%. Gupta et al. studied the uptake of Tl-201 in testes and reported an uptake of 0.9-1.2%, with no clearance to 24 hours. Use of the value reported by Gupta et al. results in an estimated dose to the testes in the adult of 0.82 mGy/MBq, and causes the testes to be identified as the highest dose organ. In our crossover study we evaluated Tl-201 uptake in the testes of 28 patients who received Tl-201 chloride plus D-Ribose, an experimental clearance agent, and Tl-201 chloride plus a placebo 7 to 14 days later. Quantitative measurements were made under a scintillation camera imaging protocol (following exercise and administration of D-Ribose or the placebo) at approximately 1.5, 4.5, 8, 24, and 48 hr, and 7 to 14 days post injection, during which the isolated testes were shielded from the body background. Images were acquired for 5 minutes at early times and 10 to 15 minutes at the latest time. The data were fit to a two component exponential curve. Uptake and clearance parameters were not significantly different between the two regimens. Mean uptake was 0.31 {plus_minus} 0.11%; the mean residence time in the testes was 0.26 {plus_minus}0.08 hr. The testes dose using this new residence time is about 0.20 mGy/MBq. This estimate should form the basis for testicular radiation dosimetry of Tl-201 chloride.

• DOE Contract Number: AC05-76OR00033
• OSTI ID: 441606
• Report Number(s): CONF-950603--
• Journal Information: Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: Suppl.5 Vol. 36; ISSN 0161-5505; ISSN JNMEAQ
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
CHLORIDES
CLEARANCE
DOSIMETRY
IMAGES
PATIENTS
RADIATION DOSES
RIBOSE
TESTES
THALLIUM 201
UPTAKE