Biodistribution and dosimetry of TC-99m P280: A phase I study
Journal Article
·
· Journal of Nuclear Medicine
OSTI ID:441637
- Harbor-UCLA Medical Center, Torrance, CA (United States)
Tc-99m P280 (a symmetrical synthetic dimer of 2 identical peptide monomers containing an RGD mimetic sequence) is a radiolabeled peptide undergoing clinical trials for use in imaging activated platelets. We investigated the biodistribution and dosimetry of intravenous Tc-99m P280 by serial determination of blood, urine and scintigraphic regional activity. Ten normal volunteers (6 male, 4 female, age 44 {plus_minus} 7) received 370 MBq (250 ug of peptide) Tc-99m P280 by intravenous injection. Twelve venous blood samples were collected over 24 hours (hrs) for calculation of blood clearance. Urine clearance was calculated by measuring the activity in the total void at 5 contiguous intervals over 24 hrs, 4 hrs and 24 hrs. The percent of the administered dose in each source organ vs. time was calculated using regions of interest created on the whole body images. Time activity curves were fit to a multi-compartmental model using the Simulation Analysis And Modeling (SAAM) software. Residence times were calculated by integration of the model predicted time activity curves and the dose estimates were performed using standard MIRD techniques. Effective dose equivalent = .010 mSv/MBq. We conclude that clearance of intravenous Tc-99m P280 is principally via the kidneys, with 89% of administered activity cleared from the blood pool within one hr, 33% excreted in the urine within one hr, and 80% excreted in the urine with 24 hrs.
- OSTI ID:
- 441637
- Report Number(s):
- CONF-950603--
- Journal Information:
- Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: Suppl.5 Vol. 36; ISSN 0161-5505; ISSN JNMEAQ
- Country of Publication:
- United States
- Language:
- English
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