Biological distribution and excretion of DTPA labeled with Tc-99m and In-111

Journal Article · Sat Dec 01 04:00:00 EST 1979 · J. Nucl. Med.; (United States)

OSTI ID:5322133

McAfee, J G; Gagne, G; Atkins, H L; Kirchner, P T; Reba, R C; Blaufox, M D; Smith, E M

For the purpose of radiation dose estimates, organ assays and excretion measurements of the Tc-99m and In-111 complexes with DTPA were conducted in dogs at various time intervals up to 24 hr, and the results compared with available human data. The peak concentration of the Tc-99m complex, at 3 min after injection, was 5% of the administered dose for one kidney, 3.5% for the liver, and 3.5% for the small bowel. No organ system except the urinary tract reached a concentration higher than that in blood for several hours after the injection. The biliary excretion of these agents was extremely low, and their elimination in the feces was negligible. In man, it appears that the residual 4 to 5% of an administered dose not eliminated in the urine by 24 hr is widely distributed in various tissues. The distribution of the In-111 complex is similar but not identical to that of the Tc-99m complex.

• Research Organization: State Univ. of New York, Syracuse
• OSTI ID: 5322133
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:12; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DOGS
DOSES
DRUGS
DTPA
ELECTRON CAPTURE RADIOISOTOPES
EXCRETION
EXPERIMENTAL DATA
HOURS LIVING RADIOISOTOPES
INDIUM 111
INDIUM ISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOLATED VALUES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METABOLISM
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIATION DOSE DISTRIBUTIONS
RADIATION DOSES
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPONSE MODIFYING FACTORS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TIME DEPENDENCE
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES