The membrane-stabilizing action of zinc carnosine (Z-103) in stress-induced gastric ulceration in rats
Journal Article
·
· Life Sciences; (United States)
- Univ. of Hong Kong (Hong Kong)
Zinc compounds have been shown to antagonize various types of gastric ulceration in rats. Zinc carnosine (Z-103), a newly developed agent was, therefore, examined for its antiulcer effect in stress-induced ulceration and also its membrane stabilizing action in rat stomachs. Cold-restraint stress induced severe hemorrhagic lesions together with increased mast cell degranulation and {beta}-glucuronidase release in the gastric glandular mucosa. A-103 pretreatment with a single oral dose reversed these actions in a dose-dependent manner. When the compound was incubated in concentrations of 10{sup {minus}7}, 10{sup {minus}6}, 10{sup {minus}5} or 10{sup {minus}4} M, with isolated hepatic lysosomes, it significantly reduced the spontaneous release of {beta}-glucuronidase in the medium. The present study not only demonstrates the antiulcer effect of Z-103 but also indicates that the protective action is likely to be mediated by its membrane-stabilizing action on mast cells and lysosomes in the gastric glandular mucosa.
- OSTI ID:
- 5863127
- Journal Information:
- Life Sciences; (United States), Journal Name: Life Sciences; (United States) Vol. 49:23; ISSN 0024-3205; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL STRESS
BODY
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
GASTROINTESTINAL TRACT
LYSOSOMES
MAMMALS
MAST CELLS
MEMBRANES
METABOLISM
METALS
MUCOUS MEMBRANES
ORGANS
PATHOLOGICAL CHANGES
RATS
RODENTS
SOMATIC CELLS
STOMACH
ULCERS
VERTEBRATES
ZINC
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL STRESS
BODY
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
GASTROINTESTINAL TRACT
LYSOSOMES
MAMMALS
MAST CELLS
MEMBRANES
METABOLISM
METALS
MUCOUS MEMBRANES
ORGANS
PATHOLOGICAL CHANGES
RATS
RODENTS
SOMATIC CELLS
STOMACH
ULCERS
VERTEBRATES
ZINC