Mucosal injury and. gamma. -irradiation produce persistent gastric ulcers in the rabbit. Evaluation of antiulcer drug binding to experimental ulcer sites

Journal Article · Wed May 01 04:00:00 EDT 1991 · Gastroenterology; (USA)

OSTI ID:5799912

Yokel, R A; Dickey, K M ^[1]

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1. Univ. of Kentucky, Lexington (USA)

A method producing persistent gastric ulcers in the rhesus monkey by combined mucosal injury and {gamma}-irradiation was modified and evaluated in the rabbit. {gamma}-Irradiation (800-1000 cGy) immediately after removal of 2-mm-diameter sections of antral mucosa resulted in ulcer craters 5-7 days later. Ulcer sites were characterized by loss of the mucosa, muscularis mucosa, and much of the submucosa. The exposed submucosa was coated with fibrin and necrotic debris infiltrated with heterophils, the rabbit equivalent of neutrophils. These ulcers strongly resemble human chronic gastric ulcers. Binding of Carafate (sucralfate; Marion Laboratories, Inc., Kansas City, MO) and Maalox (magnesia-alumina oral suspension; Wm. H. Rorer, Inc., Ft. Washington, PA) to ulcer and nearby nonulcer sites in the antrum was assessed 1 hour after drug dosing. Drug binding was determined by aluminum quantitation of stomach wall punch biopsies at necropsy. Both drugs significantly increased aluminum bound to the stomach wall compared with vehicle treatment. Significantly more antiulcer drug was bound to ulcer sites than to nearby nonulcer sites only after sucralfate administration. This model of persistent gastric ulcer should be useful to further study gastric ulcer pathogenesis and treatment.

• OSTI ID: 5799912
• Journal Information: Gastroenterology; (USA), Journal Name: Gastroenterology; (USA) Vol. 100:5 Pt 1; ISSN GASTA; ISSN 0016-5085
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALUMINIUM COMPOUNDS
ALUMINIUM HYDROXIDES
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
GASTROINTESTINAL TRACT
HYDROGEN COMPOUNDS
HYDROXIDES
IONIZING RADIATIONS
KINETICS
MAMMALS
MEMBRANES
MUCOUS MEMBRANES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
RABBITS
RADIATION EFFECTS
RADIATIONS
REACTION KINETICS
ULCERS
VERTEBRATES