Epidermal growth factor receptors in the canine antrum

Journal Article · Tue Nov 01 04:00:00 EST 1988 · Peptides (Fayetteville, N.Y.); (United States)

DOI:https://doi.org/10.1016/0196-9781(88)90211-2· OSTI ID:5703223

Zimmerman, R P; Gates, T S; Boehmer, C G; Mantyh, P W

In this study we localized receptor binding sites for /sup 125/I-human epidermal growth factor (hEGF) in the antrum of the adult canine stomach. High levels of specific /sup 125/I-hEGF binding sites were observed over the mucosa and muscularis mucosa, whereas specific binding sites were not detectable over the submucosa, external circular and longitudinal muscle or myenteric neurons. These results are in agreement with previous studies which indicated that EGF stimulates the proliferation of cultured epithelial cells and inhibits gastric acid secretion. This suggests that EGF may be a useful therapeutic agent in the healing of gastric ulcers.

• Research Organization: Center for Ulcer Research and Education, Los Angeles, CA (USA)
• OSTI ID: 5703223
• Journal Information: Peptides (Fayetteville, N.Y.); (United States), Journal Name: Peptides (Fayetteville, N.Y.); (United States) Vol. 9:6; ISSN PPTDD
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DOGS
ELECTRON CAPTURE RADIOISOTOPES
GASTROINTESTINAL TRACT
GROWTH FACTORS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
MAMMALS
MAN
MEMBRANE PROTEINS
MITOGENS
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PRIMATES
PROTEINS
RADIOISOTOPES
RECEPTORS
ULCERS
VERTEBRATES