The integration of species sensitivity and dosimetry in the extrapolation of ozone and nitrogen dioxide health data from animal to man
Conference
·
· Proc., Annu. Meet., Air Pollut. Control Assoc.; (United States)
OSTI ID:5857989
Quantitative extrapolation of animal data to man is essential if all the major effects of O/sub 3/ and NO/sub 2/ are to be considered directly in the standard setting process. For example, animal data show that these pollutants cause major structural alterations in the lung, involving chronic lung disease. The inherent nature of human clinical studies and epidemiology is such that these types of effects cannot be proven, even if they exist. Through quantitative extrapolation the risk to man of chronic lung disease upon exposure to oxidants should be possible to estimate on a scientific basis. Achieving such a goal will require a much greater knowledge of the components of extrapolation and the linkage of these components than is presently available. If the coordinated expertise of the research community is brought to bear on the topic, its achievability is inevitable.
- Research Organization:
- U.S. Environmental Protection Agency, Research Triangle Park, NC
- OSTI ID:
- 5857989
- Report Number(s):
- CONF-840612-
- Conference Information:
- Journal Name: Proc., Annu. Meet., Air Pollut. Control Assoc.; (United States) Journal Volume: 2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
CHALCOGENIDES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
EPIDEMIOLOGY
EXTRAPOLATION
HAZARDS
HEALTH HAZARDS
HUMAN POPULATIONS
INHALATION
INTAKE
LUNGS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
NUMERICAL SOLUTION
ORGANS
OXIDES
OXIDIZERS
OXYGEN COMPOUNDS
OZONE
POLLUTANTS
POPULATIONS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RISK ASSESSMENT
SENSITIVITY
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
CHALCOGENIDES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
EPIDEMIOLOGY
EXTRAPOLATION
HAZARDS
HEALTH HAZARDS
HUMAN POPULATIONS
INHALATION
INTAKE
LUNGS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
NUMERICAL SOLUTION
ORGANS
OXIDES
OXIDIZERS
OXYGEN COMPOUNDS
OZONE
POLLUTANTS
POPULATIONS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RISK ASSESSMENT
SENSITIVITY