Proceedings: new directions on the extrapolation of health risks from animals to man. Volume 1. Extrapolation from animals to man

Conference · Fri Feb 28 23:00:00 EST 1986

OSTI ID:5804929

The workshop explored various research opportunities related to the stated need. Presentations were made on historical perspectives and future research needs for improving extrapolations, the use of in vitro mutagenesis tests to evaluate potency of a compound, limitations of epidemiology studies in a regulatory environment, quantitative use of animal data in evaluating carcinogenic potency, methodologies for estimating human carcinogenesis using various dose rate equivalents, and common pharmacokinetic problems affecting interspecies comparisons. The major recommendation focused on more meaningful risk assessments through the use of pharmacokinetics to aid in the extrapolation of animal data to man. Papers on the above subjects have been abstracted separately.

• Research Organization: Meeting Planning Associates, Menlo Park, CA (USA)
• OSTI ID: 5804929
• Report Number(s): EPRI-EA-4447-Vol.1; CONF-8212109-; ON: TI86920253
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSTRACTS
ANIMALS
BIOCHEMICAL REACTION KINETICS
CARCINOGEN SCREENING
DOCUMENT TYPES
EPIDEMIOLOGY
INFORMATION NEEDS
KINETICS
LEADING ABSTRACT
MAMMALS
MAN
MEETINGS
MUTAGEN SCREENING
PRIMATES
REACTION KINETICS
RISK ASSESSMENT
SCREENING
TOXICITY
VERTEBRATES