Proceedings: new directions on the extrapolation of health risks from animals to man. Volume 2. Toxicokinetics

Conference · Sat Mar 01 04:00:00 EST 1986

OSTI ID:5885731

The workshop explored the role of toxicokinetics in the safety evaluation of chemicals when making risk assessments. This volume presents the theoretical discussions and suggested research plans. Discussions centered on species differences in absorption, plasma-protein binding, dose response curves, physiologically-based pharmacokinetic models, metabolite concentrations in toxicokinetic modeling, use of model systems in pharmacokinetics, dose-dependent kinetics and limitations of risk assessment models. Several approaches suggested for toxico-pharmacokinetic studies included DNA adduct investigations of compounds previously tested for carcinogenicity, liver-tumor hepatocyte correlations, liver-tumor/liver toxicity correlations, and pharmacokinetic evaluations and bioassays of new chemicals. Separate abstracts have been prepared for the papers.

• Research Organization: Meeting Planning Associates, Menlo Park, CA (USA)
• OSTI ID: 5885731
• Report Number(s): EPRI-EA-4447-Vol.2; CONF-8312135-; ON: TI86920254
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSTRACTS
BIOCHEMICAL REACTION KINETICS
CARCINOGEN SCREENING
CARCINOGENESIS
DISEASES
DOCUMENT TYPES
KINETICS
LEADING ABSTRACT
MEETINGS
NEOPLASMS
PATHOGENESIS
REACTION KINETICS
RISK ASSESSMENT
SCREENING
TOXICITY