Dosimetry of ozone and nitrogen dioxide in man and animals
Conference
·
· Proc., Annu. Meet., Air Pollut. Control Assoc.; (United States)
OSTI ID:5842653
The health effects of ozone (O/sub 3/) and nitrogen dioxide (NO/sub 2/) are assessed from animal toxicological, controlled human, and epidemiological studies. These assessments will be strengthened when results of animal studies can be quantitatively extrapolated to man. To achieve quantitative extrapolation, improvements are needed in the areas of dosimetry and species sensitivity. And, of course, an adequate health effect data base must exist on which to make extrapolations. The focus of this paper is to review the regional dosimetry of O/sub 3/ and NO/sub 2/ in the respiratory tract of man and animals. Dosimetry relates to estimating the amount of pollutant reaching a specific target region of the respiratory tract as a function of exposure concentration. At present, there are two approaches to dosimetry, experimental and mathematical modeling, which are discussed.
- Research Organization:
- Northrop Services, Inc., Research Triangle Park, NC
- OSTI ID:
- 5842653
- Report Number(s):
- CONF-840612-
- Conference Information:
- Journal Name: Proc., Annu. Meet., Air Pollut. Control Assoc.; (United States) Journal Volume: 2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
CHALCOGENIDES
DOSE-RESPONSE RELATIONSHIPS
EPIDEMIOLOGY
HAZARDS
HEALTH HAZARDS
HUMAN POPULATIONS
INHALATION
INTAKE
MATHEMATICAL MODELS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
OXIDES
OXYGEN COMPOUNDS
OZONE
POLLUTANTS
POPULATIONS
RESEARCH PROGRAMS
RESPIRATORY SYSTEM
TOXICITY
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
CHALCOGENIDES
DOSE-RESPONSE RELATIONSHIPS
EPIDEMIOLOGY
HAZARDS
HEALTH HAZARDS
HUMAN POPULATIONS
INHALATION
INTAKE
MATHEMATICAL MODELS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
OXIDES
OXYGEN COMPOUNDS
OZONE
POLLUTANTS
POPULATIONS
RESEARCH PROGRAMS
RESPIRATORY SYSTEM
TOXICITY