Interspecies dosimetry of reactive gases

Technical Report · Sun Mar 01 04:00:00 EST 1987

OSTI ID:6350259

Miller, F J; Overton, J H; Gerrity, T R; Graham, R C

The development of dosimetry models that can provide a description of the uptake and distribution of inhaled compounds throughout the body and the availability of animal toxicological data are integral components for a full evaluation of potential risks associated with human exposure. Interspecies dosimetric comparisons must be approached using a model conceptualization that incorporates the major factors affecting the uptake of the gas, such as respiratory tract morphology, route of breathing, depth and rate of breathing, physicochemical properties of the gas, etc. Modeling efforts thus far have primarily focused on ozone. A comparison of theoretical predictions of delivered dose of ozone to the lower respiratory tract of man shows good agreement with dose estimates derived from experimental measurements. Applications to ozone toxicological data in animals and man have been examined that incorporate the use of dosimetry models in studying quantitative dose-response relationships.

• Research Organization: Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
• OSTI ID: 6350259
• Report Number(s): PB-87-175824/XAB; EPA-600/D-87/105
• Country of Publication: United States
• Language: English

Related Subjects

500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
DOSE-RESPONSE RELATIONSHIPS
FLUIDS
GASES
MATHEMATICAL MODELS
OZONE
POLLUTION
RESPIRATION
RISK ASSESSMENT