Regional respiratory tract absorption of inhaled reactive gases

Technical Report · Mon Jun 29 04:00:00 EDT 1992

OSTI ID:6993023

Miller, F J; Overton, J H; Kimbell, J S; Russell, M L

Highly reactive gases present unique problems due to the number of factors which must be taken into account to determine regional respiratory tract uptake. The authors reviewed some of the physical, chemical, and biological factors that affect dose and that must be understood to interpret toxicological data, to evaluate experimental dosimetry studies, and to develop dosimetry models. Selected dosimetry experiments involving laboratory animals and humans were discussed, showing the variability and uptake according to animal species and respiratory tract region for various reactive gases. New experimental dosimetry approaches, such as those involving isotope ratio mass spectroscopy and cyclotron generation reactive gases, were discussed that offer great promise for improving the ability to study regional respiratory tract absorption of reactive gases. Various dosimetry modeling applications were discussed which demonstrate: the importance of airflow patterns for site-specific dosimetry in the upper respiratory tract, the influence of the anatomical model used to make inter- and intraspecies dosimetric comparisons, the influence of tracheobronchial path length on predicted dose curves, and the implications of ventilatory unit structure and volume on dosimetry and response. Collectively, these examples illustrate important aspects of regional respiratory tract absorption of inhaled reactive gases. Given the complex nature of extent and pattern of injury in the respiratory tract from exposure to reactive gases, understanding interspecies differences in the absorption of reactive gases will continue to be an important area for study.

• Research Organization: Health Effects Research Lab., Research Triangle Park, NC (United States). Environmental Toxicology Div.
• OSTI ID: 6993023
• Report Number(s): PB-92-217140/XAB; EPA--600/A-92/179
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ALDEHYDES
ANIMALS
CHALCOGENIDES
FORMALDEHYDE
INHALATION
INTAKE
LABORATORY ANIMALS
MAMMALS
MAN
MATHEMATICAL MODELS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
OZONE
PRIMATES
RESPIRATORY SYSTEM
SENSITIVITY
SOLUBILITY
SORPTION
TOXICITY
VERTEBRATES