Attenuation and cross-attenuation in taste-aversion learning in the rat: Studies with ionizing radiation, lithium chloride, and ethanol. Scientific report
The pre-exposure paradigm was utilized to evaluate the similarity of ionizing radiation, lithium chloride, and ethanol as unconditioned stimuli for the acquisition of a conditioned taste aversion. Three unpaired pre-exposures to lithium chloride blocked the acquisition of a taste aversion when a novel sucrose solution was paired with either the injection of the same dose of lithium chloride or exposure to ionizing radiation (100 rad). Similar pretreatment with radiation blocked the acquisition of a radiation-induced aversion, but had no effect on taste aversions produced by lithium aversion, but not radiation- or lithium chloride-induced aversions. In contrast, preexposure to either radiation or lithium chloride attenuated an ethanol-induced taste aversion in intact rats, but not in rats with lesions of the area postrema. The results are discussed in terms of relationships between these three unconditioned stimuli and in terms of implications of these results for understanding the nature of the proximal unconditioned stimulus in taste aversion learning.
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
- OSTI ID:
- 5857530
- Report Number(s):
- AD-A-207916/8/XAB; AFRRI-SR-89-11
- Resource Relation:
- Other Information: Pub. in Pharmacology Biochemistry and Behavior, Vol. 31, 909-918(1989)
- Country of Publication:
- United States
- Language:
- English
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Attenuation of radiation- and drug-induced conditioned taste aversions following area postrema lesions in the rat
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BEHAVIOR
BIOLOGICAL RADIATION EFFECTS
ETHANOL
BIOLOGICAL EFFECTS
LITHIUM CHLORIDES
RESPONSE MODIFYING FACTORS
AVOIDANCE
DOSES
IONIZING RADIATIONS
LEARNING
PROGRESS REPORT
RATS
SOLUTIONS
STIMULI
ALCOHOLS
ALKALI METAL COMPOUNDS
ANIMALS
CHLORIDES
CHLORINE COMPOUNDS
DISPERSIONS
DOCUMENT TYPES
HALIDES
HALOGEN COMPOUNDS
HYDROXY COMPOUNDS
LITHIUM COMPOUNDS
LITHIUM HALIDES
MAMMALS
MIXTURES
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals