Radioprotection of mice by a single subcutaneous injection of heat-killed Lactobacillus casei after irradiation
- Yakult Central Institute for Microbiological Research, Tokyo (Japan)
Treatment of whole-body gamma-irradiated mice with a preparation of Lactobacillus casei (LC 9018) immediately after irradiation caused a sustained increase in serum colony-stimulating activity which was followed by an enhanced repopulation of granulocyte-macrophage colony-forming cells in the femoral marrow and spleen. Numbers of blood leukocytes, erythrocytes, and platelets were increased earlier in the treated mice than in the controls, and the survival rate was elevated significantly. The radioprotective effect was dependent on the dose of LC 9018 as well as on the dose of radiation. These results demonstrate the value of LC 9018 for the treatment of myelosuppression after radiotherapy or radiation accidents.
- OSTI ID:
- 5838616
- Journal Information:
- Radiation Research; (USA), Vol. 125:3; ISSN 0033-7587
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LACTOBACILLUS
RADIOSENSITIVITY EFFECTS
COLONY FORMATION
DOSE-RESPONSE RELATIONSHIPS
GAMMA RADIATION
MICE
RADIOPROTECTIVE SUBSTANCES
WHOLE-BODY IRRADIATION
ANIMALS
BACTERIA
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICROORGANISMS
RADIATIONS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals